Department: Electrical and Computer Engineering Department
Faculty: Faculty of Engineering and Technology
Specialization: Medical Image Analysis
FRQ Research Area: Natural Sciences and Technology
Host university: McGill University
Host Department: BIOPHYSICAL CHEMISTRY AND BIOPHYSICS
Canadian Partner: Prof. Paul Wiseman
Research Domain: Cluster analysis and quantification of super-resolution microscopy data
Research Project Title: Computational Analysis of Cystic Fibrosis Super-resolution Microscopy Data
Research Project Purpose: Super-resolution single molecule localization microscopy (SMLM) network analysis and machine learning to identify structural changes in cystic fibrosis (CF) patients carrying the F508del mutation in the cystic fibrosis transmembrane regulator (CFTR).
Expected Results: These studies will identify the best anti-CFTR antibody, define the appropriate labeling conditions, and determine network analysis features that best discriminate between normal and mutant CFTR clusters.