Dr. Mohammed Qaisiya

Dr. Mohammed Qaisiya

PQSB 3rd Call Participant
Hebron University

Department: Laboratory Medical Sciences

Faculty: Pharmacy

Specialization: Functional genomics, molecular biology and biochemistry

FRQ Research Area: Health Sciences

Host university: Laval University

Host Department: Dept. of Microbiology-Infectiology and Immunology, Faculty of Medicine

Canadian Partner: Prof. Patrick Provost

Research Domain: Molecular Biomedicine

Research Project Title: "Extracellular vesicles in Camel milk: Evaluating the effects of exosomes on fatty liver disease".

Research Project Purpose: Fatty liver disease is a condition that describes an accumulation of excess fat in the liver. The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and it is the most common cause of chronic liver disease. No medicines have been approved to treat NAFLD and it is predicted to become the leading cause of liver transplantation by 2025. Liver biopsy considered as the gold standard of diagnosis but it cannot be proposed to each individual patient in clinical practice. Recent studies indicate that circulating miRNAs could serve an accurate diagnostic biomarker for NAFLD. In the Middle East, people consume camel milk regularly as it is believed to have beneficial effects on health and protect against several diseases. Camel milk is the closest to a human mother's milk and the beneficial effects of milk might come from their nanoparticles, especially exosomes. Till now, there is no data whether exosomes derived from camel milk have effects (if any) on the accumulation of fats in liver and if they can play an important role in protection against the progression of liver diseases. 

Expected Results:

  1. Learn the molecular techniques and skills used for isolation of miRNAs and EVs from serum and milk. 
  2. Identify of non-invasive biomarkers and designing of potential therapeutic miRNA-based strategies to diagnose and treat NAFLD.
  3. Isolate and characterize exosomes from Camel milk and evaluate their effects on models of NAFLD (in collaboration with Prof. Claudio Tiribelli from Italian Liver Foundation).