Hasan Mohammad Sbaihat

Hasan Mohammad Sbaihat

PGSB Returner Fellows
Institute of Neuroscience and Medicine 4- FZJ, RWTH Aachen University and Arab American University Palestine - AAUP

Specialization: Neuroscience and Medicine

Accurate Specialization: Functional magnetic resonance imaging – activity and connectivity. 

Research Cluster: Neuroscience Research Cluster

FZJ Supervisor: Univ.-Prof. Dr. med. Irene Neuner, MHBA
    
Center in Juelich: Institute of Neuroscience and Medicine 4

Affiliated University in Germany: RWTH Aachen University

Department: Psychiatry and Psychotherapy

Faculty: Faculty of medicine

Going Projects: Functional near-infrared spectroscopy

Contributions relevant to PGSB and Palestine:  The proposed project intersects at certain points with another study currently being conducted at the INM-4 institute by Ph.D. student Nibal Khudeish. Accordingly, the study is very likely to be merged and used to support another researcher. Also, the majority of the work will be done in Palestine, in institutions such as the AAUP and the Patient's Friend's Society that are passionate about improving research and using the newly developed research approach. Such institutions would benefit from this collaboration since it is both appropriate and efficient. Therefore, this approach will raise the standard of research in Palestine. Moreover, the project will provide opportunities for Palestinian students who are interested and motivated to work on this research under the supervision of a postdoctoral candidate.

Host Palestinian University: Arab American University Palestine - AAUP

Host Department: Medical Imaging Department

Palestinian Partner: Dr. Abed AL-Nasser Assi

Research Project Title: Investigating the dynamics of task-induced modulation and test-retest stability in the triple resting-state networks using functional magnetic resonance imaging.

Research Project Interest: The interest of this Project is to use reliable and precise imaging modalities such as the functional magnetic resonance imaging to investigate the regional spontaneous brain activity and functional connectivity during resting-state conditions. Such investigation is a promising and potential used methodology for understanding human brain organization. Also using this imaging approach helps identify biomarkers for mental diseases.

Research Goal: Performing a research work that explores the attributes of RSN activity and connectivity, which can be accomplished by studying the clinical neurosciences disorders that will lead to a deep understanding of their dysfunction.

Research Project Purpose: The postdoctoral researcher will teach the students in AAUP and all interested universities how to acquire, pre-process, and analyze the data while considering the quality control protocols and making use of the experiences he gained during his doctoral work in the Institute of Neuroscience and Medicine - 4 Juelich Research Center, Germany. Two imaging modalities will be included the functional magnetic resonance imaging and the Functional near-infrared spectroscopy (fNIRS).

Main expected outputs/ results: We expected to find new brain networks attributes due to the clinical neurosciences disorders are abundant in Palestine, e.g., generalized anxiety disorder, panic disorder, post-traumatic stress disorder (PTSD), and depression. A previous study was performed mainly by the World Health Organization to assess the psychiatric diagnostic in four countries (Algeria, Cambodia, Ethiopia, and Palestine). The results indicated that the most prominent risk ratio for PTSD is in Palestine. 

Expected future impact: Finding a new brain networks attributes is meaningful promise to be used for understanding, detecting, and distinguishing psychiatric disorders and holds the possibility for developing available neuroimaging biomarkers for different psychiatric disorders.

Future Plan: Including a different type of psychiatric disorders in our research project.

Publication:

  • Sbaihat H, Rajkumar R, Ramkiran S, Assi AA, Shah NJ, Veselinović T, Neuner I. Dynamics of task-induced modulation of spontaneous brain activity and functional connectivity in the triple resting-state networks assessed using the visual oddball paradigm. PLoS One. 2021 Nov 4;16(11): e0246709. doi: 10.1371/journal.pone.0246709. PMID: 34735449; PMCID: PMC8568109. 
  • Hasan Sbaihat, Ravichandran Rajkumar, Shukti Ramkiran, Abed Al-Nasser Assi, Jörg Felder, N. Jon Shah, Tanja Veselinović, Irene Neuner. Test-retest stability of spontaneous brain activity and functional connectivity in the core resting-state networks assessed with ultra-high field 7-Tesla resting-state fMRI. Human brain mapping, 1-15. 2022. DOI: 10.1002/hbm.25771.
  • Altinok DCA, Rajkumar R, Nießen D, Sbaihat H, Kersey M, Shah NJ, Veselinović T, Neuner I. Common neurobiological correlates of resilience and personality traits within the triple resting-state brain networks assessed by 7-Tesla ultra-high field MRI. Sci Rep. 2021 Jun 2;11(1):11564. doi: 10.1038/s41598-021-91056-y. PMID: 34079001; PMCID: PMC8172832.
  • Cláudia Brambilla, Tanja Veselinovic, Ravichandran Rajkumar, Joerg Mauler, Andreas Matusch, Andrej Ruch, Linda Orth, Shukti Ramkiran, Hasan Sbaihat, Nicolas Kaulen, Nibal Khudeish, Christine Wyss, Karsten Heekeren, Wolfram Kawohl, Elena Rota Kops, Lutz Tellmann, Jürgen Scheins, Frank Boers, Bernd Neumaier, Johannes Ermert, Markus Lang, Stefan Stüsgen, Hans Herzog, Karl-Josef Langen, Jon Shah, Christoph Lerche, and Irene Neuner. mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [11C]ABP688 PET/MR-EEG. Transl Psychiatry 12, 6 (2022). https://doi.org/10.1038/s41398-021-01763-3
  • Nicolas Kaulen, Ravichandran Rajkumar, Claudia Régio Brambilla, Jörg Mauler, Shukti Ramkiran, Linda Orth, Hasan Sbaihat, Markus Lang, Christine Wyss, Elena Rota Kops, Jürgen Scheins, Bernd Neumaier, Johannes Ermert, Hans R. Herzog, Karl-Joseph Langen, Christoph Lerche, N. Jon Shah, Tanja Veselinović, and Irene Neuner. mGluR5 and GABAA Receptor Specific Parametric PET Atlas Construction - PET/MR Data Processing Pipeline, Validation and Application. Human brain mapping, 2022 January 1-15. DOI: 10.1002/hbm.25778. 
  • mapping.
  • 7T Mental health: Functional alterations in resting-state within the executive control network and its association with BDI-II and TMT-B in MDD by Ravichandran Rajkumar, Gereon Johannes Schnellbächer, Hasan Sbaihat, N. Jon Shah, Tanja Veselinović, and Irene Neuner. This work has been accepted and published as conference abstract in International Society for Magnetic Resonance in Medicine. https://www.ismrm.org/21/program-files/TeaserSlides/TeasersPresentations/1664-Teaser.html