Dr. Nisreen Alhaj

Dr. Nisreen Alhaj

Faculty Member-Organic chemistry
An-Najah National University & University of Bordeaux

Department: Chemistry

Faculty: Science

Specialization: Organic chemistry

Host French partner: University of Bordeaux

Host Department: Institut des Sciences Moléculaires (ISM)

French Partner: Emilie GENIN

Research Domain: Organic Chemistry

Research Project Title: Synthesis, antimicrobial, anticancer, and neuroprotective inhibitory activities of a novel privileged heterocyclic motif

Research Project Purpose: The design and synthesis of physiologically active molecules is an essential field in chemistry since there are still many ailments for which there are no effective treatments. Antimicrobial and cancer therapy remain a major health concern worldwide. As a consequence, new antibacterial, antifungal, and anticancer drugs with better activity profiles are in high demand. The purpose of this study is to discover lead inhibitors that can be manufactured at a low cost utilizing the convergent multicomponent technique. As a consequence, drugs produced from these leads will meet the cost criterion, which is a vital prerequisite for disease-fighting drugs.

The aims of this study are: Firstly, developing efficient syntheses of a series of 3-aminoimidazo[1,2-a] heterocycles required for biological screenings. Secondly, testing the antimicrobial activity of the synthesised compounds against some clinical and resistant pathogens. Thirdly, evaluating the free radical scavenging properties of the prepared heterocycles. Fourthly, assessing the cytotoxicity against cancer cells. Finally, Assessing the effects of non-benzodiazepine structures on various AMPA-type receptors expressed in some cell lines using the whole-cell patch clamp technique

Main outputs/results: This project is expected to finish up with a variety of novel compounds of Imidazo[1,2-a]pyridine derivatives for specific biological activities. The two stages of this project are equally important; in the first step, Groebke-Blackburn-Biennayme reactions will be used  which represent an alternative to the sequential multistep synthesis. The produced compounds are expected to have extraordinary bioactivities and speeding up the Structure-Activity Relationship studies

Expected future impact: This collaboration is expected to finish up with both scientific and professional outcomes. On the scientific side, the synthesis of the molecules and their biological role is a precious contribution in the organic and medicinal chemistry fields. On the professional side, this collaboration helps the Palestinian team to fill the great shortage in research equipment and instrumentation. Moreover, it could open new opportunities for new collaborations between other French and Palestinian teams as a result of the short exchangeable visits, meetings and conferences. 

Future Plan: The current project focuses on the medicinal chemistry as the main application of our organic compounds. It is intended to extend the collaboration in this field by preparing additional compounds and assessing their biological activities.

Main Impact: Producing compounds with extraordinary bioactivities that can be manufactured at a low cost will meet the cost criterion, which is a vital prerequisite for disease-fighting drugs.